Mr. Big Stuff hit the number two spot on Billboard Hot 100 chart upon its release.
It spent another five weeks in the top spot on Billboard Soul Singles chart.
Knight got a Grammy nod for Best R&B Vocal Performance, Female for the track.
'New Orleans and her global fan base join together in gratitude for the indelible mark she left on the world,' her family said.
"Mr. Big Stuff" from 1971's Mr. Big Stuff.